The tumour suppressor p53 is now known to be an ancient transcription factor that had already evolved interaction sites with its partner protein MDM2 at the dawn of multi-cellular eukaryotic animal life.The billion-year life history of the p53-MDM2 axis has permitted significant time for the proteins to integrate into a distinct range of cellular p

Many 3 Piece Queen Platform Bed efforts are being made to cope with negative consequences of climate change (CC) on livestock.Among them, selective breeding of resilient animals to CC is presented as an opportunity to maintain high levels of performance regardless of variation in weather.In the present work, we proposed a set of breeding strategies

Background: Alcohol use disorder (AUD) is a major public health concern in South Africa (SA).Abrupt cessation or reduction of alcohol intake in chronic users can result in withdrawal symptoms.Benzodiazepines are the treatment of choice but need to be used cautiously in patients with a lifetime history of substance abuse given their highly addictive

The use of psychostimulants and alcohol disrupts blood-brain barrier (BBB) integrity, resulting in alterations to cellular function, and contributes to neurotoxicity.The BBB is the critical boundary of the central nervous system (CNS) where it maintains intracellular homeostasis and facilitates communication with the peripheral circulation.The BBB

Ice flow velocity is a vital parameter for estimating the ice mass balance of glaciers in Antarctica.Especially long time serial observation of the surface velocity is of great significance to assessing the relationship between Antarctic ice materials and global climate change.However, the Knitwear existing research on Antarctic ice velocity based